Severe allergies to the new crown vaccine in the United States

According to the “New York Times” report on December 25, the Moderna new crown vaccine, which began mass vaccination on Monday, has the first severe allergy case in the United States. On the 24th local time, Hussein Sadrzad, an oncologist at the Boston Medical Center in the United States, developed a severe allergic reaction a few minutes after being injected with the Moderna new crown vaccine.

At the same time, the U.S. Food and Drug Administration (FDA) advisory committee issued a warning against Moderna’s new crown vaccine that people who have undergone facial cosmetic filling may have side effects after vaccination, including facial swelling or inflammation.

Prior to this, the Pfizer vaccine, which was injected earlier, had experienced severe allergic reactions in the United Kingdom and the United States.

The FDA warned: Facial cosmetic fillers cause side effects from new crown vaccination. According to US TMZ Magazine

With the large-scale vaccination of the new crown vaccine in many countries around the world, cases of severe allergic reactions after vaccination have triggered people’s anxiety about whether they should be vaccinated. Scientists are also paying close attention to this issue, and recently “picked out” the possible “culprit”-compound polyethylene glycol (PEG).

People who have received cosmetic fillers may have side effects but no major problems

According to the New York Post report on the 25th, the FDA advisory committee issued a warning against Moderna’s new crown vaccine, stating that people who have undergone facial augmentation cosmetic surgery may have side effects after vaccination, including facial swelling or inflammation.

According to the committee, some trial participants who have undergone facial augmentation have experienced side effects. ABC News reported that California dermatologist Dr. Shirley Qi introduced that in these cases, all patients had swelling and inflammation in the area where the filler had been injected. Some people had cheek fillers 6 months before vaccination, and another patient had lip fillers 2 days after vaccination, but all the allergic reactions disappeared after receiving steroids and antihistamines. .

Dr. Qi said that this is an immune response. “After being vaccinated, the immune system will speed up. This is the normal working principle of the vaccine. So when (immune cells) find some substances that are not naturally present in the body, they will attack, and an immune response will occur in these areas. It makes sense.”

She also pointed out that the side effects of this vaccine are easy to treat, and people should not refuse vaccination on this ground.

“Locking in” the “true culprit” of allergies exists in both vaccines

Currently, regulatory agencies in various countries have stated that they are closely monitoring the allergies related to the new crown vaccine and are planning to conduct further studies.

However, according to the “Wall Street Journal” report on the 25th, scientists have identified a “culprit” that may cause severe allergic reactions-compound polyethylene glycol (PEG), and this ingredient is in both Pfizer vaccine and Moderna vaccine All exist.

“Although it is only our speculation at present, it is well known that the same ingredient in both vaccines, namely PEG, may be related to allergic reactions, although this situation is very rare.” US Food and Drug Administration (FDA) Bio Peter Marks, director of the Product Evaluation and Research Center, said at a press conference on the 18th.

Both Pfizer vaccine and Moderna vaccine are mRNA vaccines. The working principle of this type of vaccine is that mRNA enters human cells and teaches the cells to produce a protein similar to the spike protein on the surface of the new coronavirus, which triggers a special immune response. When the body is exposed to the real new coronavirus, it Can support the body’s defense system.

PEG is a component in the fatty membrane that wraps the mRNA, and the fatty membrane containing PEG helps to ensure that the mRNA enters the cell through the cell membrane.

In this regard, some allergy specialists and immunologists countered that PEG exists in a series of daily necessities such as toothpaste, shampoo and medicine. Some previous vaccines also contained these compounds, but allergies to PEG are extremely rare. It is not excluded that other substances in the new crown vaccine cause severe allergic reactions.

Scientists have identified the “culprit” that may cause severe allergic reactions-compound polyethylene glycol (PEG). According to “Science” magazine

According to a report in “Science”, PEG has never been used in an approved vaccine before, and it appears in many drugs that occasionally cause potentially life-threatening allergic reactions. Symptoms include skin rash, sudden drop in blood pressure, shortness of breath, and rapid heartbeat. .

Some scientists have pointed out that certain types of PEG are more likely to cause allergic reactions than others. Elizabeth Phillips, director of the Center for Drug Safety and Immunization at Vanderbilt University Medical Center, explained, “(Although) both belong to the PEG family, they are not the same in terms of allergic potential. The heavier PEG types are usually easier Cause an allergic reaction.”

James Baker, an immunologist at the Institute of Nanotechnology Medicine and Biological Sciences at the University of Michigan, pointed out that the PEG in the new crown vaccine is different from the PEG that has been associated with allergic reactions in the past. “The overall structure (of the PEG in the new crown vaccine) is very different from previous vaccines,” he said. Therefore, it is difficult to judge the difference between the allergic reaction to PEG in the new crown vaccine and the allergic reaction to other PEGs.

Professionals: Allergies should not prevent continued vaccination

At present, it is still uncertain whether the allergic reactions that have occurred so far are typical allergic reactions, that is, an immune response involving an antibody called immunoglobulin E (IgE).

Baker said: “We must consider all possibilities.” The Wall Street Journal reported that both Baker and Phillips recently participated in a video conference held by the National Institute of Allergy and Infectious Diseases (NIAID) to discuss allergic reactions to the new crown vaccine. NIAID said it is currently designing a study to examine this issue more closely.

Daniel Rotson, director of NIAID’s Allergy, Immunization and Transplantation Department, responded in an email: “Although PEG may be the culprit, we need to remain open to other possibilities.”

However, scientists emphasized that the new crown vaccination should continue. “We need to be vaccinated,” Phillips told Science magazine. “We need to work hard to contain this epidemic. But at the same time we urgently need more relevant data.

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